Would you consider giving thrombolytic therapy for patients with acute vision loss concerning for CRAO based on history and within the window before any ophthalmological assessment and confirmation?   

We have utilized a prior study to give tPA or tenecteplase within 4.5 hours of onset for CRAO. I would not do so, however, without an ophthalmology evaluation to confirm the likely diagnosis and to exclude an alternative diagnosis such as a retinal detachment.

This is a comment for the author of this question. The answer is a matter of general principles of medical practice: when a patient presents with a serious or life-threatening new neurological or other symptom in an ED, which has a differential diagnosis including at least 2 diagnoses that are treat...