Would you consider neoadjuvant endocrine therapy in a postmenopausal patient with ER + locally advanced breast cancer with nodal disease who wants to avoid chemotherapy?

While neoadjuvant endocrine therapy should not be presented to patients as a standard-of-care, it may be an appropriate option for certain carefully counseled patients. I would consider it reasonable in a patient for whom chemotherapy would NOT be an option (e.g. too frail, too unhealthy, or patient...

I view endocrine therapy with an AI as a standard preoperative approach for locally advanced ER-positive breast cancer in a postmenopausal woman. Biologically, most of these tumors remain endocrine sensitive, many are neglected, or have been there for a long time as reflected by lower grade, low pro...

I generally would not use neoadjuvant endocrine therapy for a patient with locally advanced (eg. clinically stage 3) breast cancer. To be fair, there is a possibility that low grade tumor, and/or one that is found to result in a drop in Ki-67 to <10% on endocrine therapy (with the caveat that Ki-67 ...