Would you consider offering adjuvant Olaparib to a patient with early stage triple negative breast cancer, cT3N0, ypT1aN0, with BRCA VUS who has residual disease after neoadjuvant KEYNOTE-522 regimen?
Would you be more inclined to use it if a patient had early discontinuation of pembrolizumab due to IRAE?
Answer from: Medical Oncologist at Academic Institution
Patients with TNBC and residual disease have several options. As trials of different approaches ran roughly concurrently, we lack data on how/when to combine, sequence, or choose. The capecitabine and olaparib trials did not include patients on IO therapy that would continue to the adjuvant setting....
Comments
Medical Oncologist at Avita Health System Giving very expensive and potentially toxic therap...
Medical Oncologist at NYU Winthrop Hospital I will not - as per the NCCN guidelines.
Giving very expensive and potentially toxic therap...
I will not - as per the NCCN guidelines.