Would you give T-DXd to patients with resolved drug-induced ILD from other agents such as prior chemo/targeted therapy/immunotherapy?  

Depending on the pathophysiology and prior offending agent, I would consider treating such patients with TDxd. Ado-trastuzumab emtansine has been rarely associated with ILD; in this particular case, ILD caused by another HER2-targeting ADC, unless it was grade 1, I may not consider challenging the p...

The use of T-DXd in patients with resolved drug-induced Interstitial Lung Disease (ILD) from prior treatments should be carefully considered as T-DXd has been associated with ILD. The prescription information includes a warning about this risk. Hence, the decision to use T-DXd in such cases should b...