Would you manage a subtotally resected pilocytic astrocytoma with deleted CDKN2A differently than one with intact CDKN2A?

> 50-year-old woman with a pilocytic astrocytoma of the 4th ventricle (biopsy only). Caris shows BRAF intact and deleted CDKN2A/B.

Answer from: Radiation Oncologist at Academic Institution

Among brain tumors, CDKN2A loss has the greatest clinical implications in histologically low and intermediate grade gliomas. In IDH-mutant astrocytomas, the presence of homozygous deletion of CDKN2A is associated with poor outcome. Usually, pilocytic astrocytomas (grade 1) have a very good prognosis...

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Radiation Oncologist at Icahn School of Medicine at Mount Sinai
I very much agree with the thoughtful input of Dr....

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Would you manage a subtotally resected pilocytic astrocytoma with deleted CDKN2A differently than one with intact CDKN2A?

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