Would you offer additional systemic treatment to a stage II or III resected colon cancer that received 3 months of adjuvant capecitabine/oxaliplatin and now is presenting with a solitary lung metastasis?  

Thanks for the question!First, it is important to clarify whether this lesion developed during or right after adjuvant CAPEOX, if so, there is no point in continuing adjuvant CAPEOX (it is very important to compare with baseline restaging scans performed before starting adjuvant therapy, as solitary...

I agree with Dr. Sahin, however, if lung nodule is new and developed more than 12 months from adjuvant therapy, I would suggest ctDNA, followed by surgical resection, then can monitor with ctDNA, if becomes negative then just close monitoring with ctDNA and scans, if positive, would suggest systemic...