Would you offer BM biopsy as the next step for progressive thrombocytosis when peripheral blood is negative for JAK2, CALR, and MPL mutations for MPN diagnosis?

Answer from: Medical Oncologist at Community Practice

Yes, definitely. Always need bone marrow morphology to diagnose MPNs. Triple-negative ET or PMF comprises 5-10% of all ET and PMF and lacks the 3 canonical driver mutations, i.e., in the JAK2, CALR, and MPL genes.

Comments

Medical Oncologist at Wentworth Douglass Hospital
What if it is stable non-progressive thrombocytosi...

Medical Oncologist at The Center for Hematology and Oncology at Holy Cross Hospital
Agree with marrow evaluations

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Would you offer BM biopsy as the next step for progressive thrombocytosis when peripheral blood is negative for JAK2, CALR, and MPL mutations for MPN diagnosis?

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