Would you offer SBRT in a patient with history of CRC, subsequently found to have a solitary liver metastasis treated with chemotherapy followed metastasectomy with positive margins?  

This is a difficult scenario, as there is little data to guide whether we should be radiating adjuvantly post metastectomy. My answer to this question would be, it depends. The rationale for offering adjuvant radiation in the setting of an R1 hepatic metastatectomy is based on multiple studies that...