Would you recommend adjuvant tamoxifen in premenopausal woman with high grade DCIS and familial CHEK2 mutation who had bilateral mastectomies?   

While risk of CBC is higher in women with known PV in CHEK 2 1100delC (Kriege et al., PMID 24918820), bilateral mastectomies offers the greatest risk reduction for this premenopausal woman with high grade DCIS and pathogenic germline CHEK2 mutation. Results from CPM in high risk individuals consiste...