Would you recommended adjuvant endocrine therapy for a high grade DCIS, ER negative, but PR positive that has underwent lumpectomy and adjuvant radiation?  

I would not recommend adjuvant endocrine therapy to a patient with high grade DCIS that was ER-negative and PR-positive. Studies such as NSABP B-23 failed to demonstrate a benefit to the addition of tamoxifen to chemotherapy in patients with ER-negative invasive cancers, which has been confirme...