Would you transition from denosumab to anabolic agents in patients who are in urgent need for extensive dental work?
Answer from: at Academic Institution
From my experience, this is a catch-22. If you stop the Denosumab you will markedly increase osteoclastic activity throughout the entire skeleton which is why it is recommended that you not stop the medication without some other intervention. I have had several patients with either osteonecrosis of ...
Comments
Medical Oncologist at New England Cancer Specialists It would be great to see if there are data on teri...
at Cedars-Sinai Medical Center Doesn’t prior treatment with antiresorptives...
at Florida Medical Center Nice summary of the above, although the effects ar...
I agree with Dr. @Holick. Teriparatide and abaloparatide are remodeling-based anabolic drugs. When you stop denosumab there is increased osteoclastic activity and loss of BMD. If you start a PTH anabolic the anabolic response is often quite robust Ignore BMD for a second and think about the biology ...
It would be great to see if there are data on teri...
Doesn’t prior treatment with antiresorptives...
Nice summary of the above, although the effects ar...