Would you treat an isolated elevated total cholesterol in a post-menopausal patient who is otherwise healthy and has no significant CV risk factors?  

This is not a simple yes or no question as asked, particularly with the limited information provided. Whether I would pharmacologically treat such a patient would depend on her actual lipid values. What are her LDL, HDL and triglyceride values? On the one hand, a total cholesterol could be elevated ...

I agree fully with Dr. @Kraemer's answer. The information provided is not sufficient to provide an answer on what kind of treatment is needed at this time.  To add to the answer already provided by Dr. @Kraemer, additional information on  "What is the woman's age?", another important ques...