Would you use enzalutamide concurrently in combination with radium-223?

In light of the data from ERA223 showing increased deaths and fractures with the combination of radium-223 and abiraterone compared to abiraterone alone, do you have reservations about combining radium-223 with enzalutamide?

Answer from: Medical Oncologist at Academic Institution

In ERA223, men with asymptomatic to minimally symptomatic, chemotherapy-naive, metastatic castration-resistant prostate were randomized to receive either radium-223 OR placebo (6 cycles), administered concurrently with abiraterone acetate/prednisone. In December 2017, the independent data/safety mon...

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Radiation Oncologist at Penn Medicine
If the patient is currently on abiraterone or enza...

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Would you use enzalutamide concurrently in combination with radium-223?

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