Are there any special treatment considerations when treating a patient with laryngeal cancer with significant Reinke's edema of the vocal folds?  

If possible, I would collaborate with the ENT/ORL who diagnosed Reinke's edema. Reinke's is often from smoking and then I'd counsel smoking cessation. Sometimes it can be from reflux or hypothyroidism - so treat that if that's the issue. I would also be sure you are confident of the local extent/sta...

If you are treating the ipsilateral/involved cord only, then you would want to be mindful of changes in edema/anatomy through the course of RT.