Are there any successful disease modifying therapy for diffuse idiopathic skeletal hyperostosis (DISH)?  

Therapy for DISH is largely supportive: PT, NSAIDs/pain relievers, and control of contributing metabolic conditions, nutrition, exercise, and lifestyle changes; when necessary surgical interventions such as surgical resection of osteophytes and spinal fusion are required.Clinical research in DISH is...

There are no disease modifying agents for DISH and there is no available evidence that controlling the associated metabolic diseases has a disease modifying effect. Most patients with DISH, in spite of the sometimes exuberant changes on imaging, are asymptomatic. Many patients are diagnosed on the ...