Is there any role for administering another course of recombinant zoster vaccine (Shingrix) in a previously vaccinated patient with RA, who is in clinical remission on JAK inhibitor but has had a breakthrough shingles infection?  

Recombinant zoster vaccine is quite immunogenic compared to other vaccines, so an immunocompromised person who previously received the 2-dose course (especially before severe immunosuppression with a Jak inhibitor) is likely to have a robust immune response and protection against zoster for many yea...

Dr. @Liang has provided a very complete and literate response. However, the critical word is “likely”. As with most vaccines, both the strength and the duration of response to the zoster vaccine decline with worsening levels of immunosuppression. We have increasingly adopted the practic...