Please select the option that best describes you:
Are you comfortable combining relugolix with enzalutamide or abiraterone?
Current NCCN guidelines recommended not combining relugolix with these agents until more data is available.
Any drug interaction concerns or other specific considerations for the combination?
Answer from: Medical Oncologist at Academic Institution
I usually avoid these combinations. The challenge is that relugolix is not superior to other ADT methods in terms of efficacy (at least based on available data) but there are safety issues with considering these combinations. All three of these medications are substrates for similar enzymatic metabo...
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Answer from: Medical Oncologist at Community Practice
A phase I study testing the combination of relugolix and abiraterone or apalutamide showed favorable safety and tolerability profile. The effects on the levels of testosterone were also maintained after transitioning from other ADTs to relugolix (De La Cerda et al., PMID 37060432). The The REAL...
Comments
Medical Oncologist at Houston Methodist
We recently reported the combinatorial approach sa...
We recently reported the combinatorial approach sa...
Medical Oncologist at Stanford School of Medicine
Any concerns related to diminished efficacy @Eleni...
Any concerns related to diminished efficacy @Eleni...