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At what point would you consider anticoagulation in a pregnant patient with lupus nephritis and non-nephrotic range proteinuria?

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Mednet Member
Mednet Member
Rheumatology · UT Southwestern Medical Center

If the patient does not have APS and does not have nephrotic range proteinuria, then the indication for presumptive anti-coagulation is unclear.

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Mednet Member
Mednet Member
Rheumatology · University of Chicago

I would consider prophylactic anticoagulation with heparin or low molecular weight heparin for a pregnant patient with lupus nephritis and non-nephrotic range proteinuria if they had positive antiphospholipid antibodies and the patient had prior pregnancies that resulted in losses, pre-eclampsia, pl...

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Mednet Member
Mednet Member
Rheumatology · University of Chicago

I came upon this and thought I'd share for this question. These are the UK's Guidelines for Renal disease management in pregnancy.

Guideline 4.5.1

We recommend that women with nephrotic-range proteinuria (uPCR> 300 mg/mmol or ACR > 250 mg/mmol) be offered thromboprophylaxis with low molecular weight ...

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