At what stage of the neuropathy workup do you screen for B6 toxicity?  

In my experience, vitamin B6 deficiency due to poor oral intake is very uncommon. However, toxicity may occur with supplementation typically more than 2 gm/day, although chronic use of 50 mg/d may also be a cause. Vitamin B6 is present in many supplements and toxicity may cause direct damage to the...

I’ve found that many of my younger patients who present with B6 toxicity get it from the overuse of certain energy drinks. For instance, a single shot of a 5-hour energy drink has about 2000% of your daily recommended value of B6.