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General Internal Medicine

Adrenal Disorders   

Questions discussed in this category

Do you recommend combined baseline cortisol and DHEA-S testing to improve the efficiency and accuracy of adrenal insufficiency diagnosis?
1 Answer available
Do patients with central adrenal insufficiency on maintenance hydrocortisone therapy require doubling of their corticosteroid during chemotherapy cycles?
1 Answer available
What clinical sign or symptom do you consider to be the most specific for Cushing syndrome?
1 Answer available
In your practice, when do you opt to treat unilateral primary hyperaldosteronism medically rather than surgically?
1 Answer available
Do progesterone only oral contraceptive pills affect cortisol binding globulin?
1 Answer available
What 60 minute cortisol threshold value do you use for diagnosis of adrenal insufficiency after ACTH stimulation?
Zha et al., PMID 35487459
5 Answers available
In what clinical scenarios should we use the 2-day 2mg DST instead of the 1mg overnight DST for screening of Cushing syndrome?
1 Answer available
Should oral combined contraceptives be held prior to overnight dexamethasone suppression test to rule out Cushings?
If so, how long should OCPs be held to reliably trust the dex suppression test results?
2 Answers available
Is it possible to have undetectable cortisol levels in secondary adrenal insufficiency?
Young, previously healthy male with normal growth presenting with two syncopal episodes. Currently, only symptom is mild fatigue. Labs showed: Cortiso...
2 Answers available
What further work-up (if any) should be considered in patients with pituitary microadenoma and stigmata of Cushing's disease but low ACTH and repeatedly normal plasma, urinary, and salivary cortisol levels?
1 Answer available
Is there an indication for adrenalectomy in patients with subclinical Cushing syndrome and adrenal nodule?
1 Answer available
Are there instances when you would recommend against pursuing adrenal vein sampling in a patient with primary hyperaldosteronism and normal adrenal imaging?
1 Answer available
What is your preferred method for confirming the diagnosis of primary aldosteronism in a patient with an elevated plasma aldosterone to renin ratio?
1 Answer available
Is a significant rise in cortisol post cosyntropin stimulation sufficient to rule out adrenal insufficiency in patients with low albumin?
1 Answer available


Papers discussed in this category

The Journal of clinical endocrinology and metabolism, 2016-05
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2019-02
THE EVALUATION OF INCIDENTALLY DISCOVERED ADRENAL MASSES.
European journal of endocrinology, 2023 Jul 20
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2020 Sep
Adrenal Vein Sampling Without Discontinuation of Mineralocorticoid Receptor Antagonist Therapy.
European journal of endocrinology, 2022 Nov 22
Cardiovascular outcomes and all-cause mortality in primary aldosteronism after adrenalectomy or mineralocorticoid receptor antagonist treatment: a meta-analysis.
Journal of cardiovascular development and disease, 2022 Sep 08
Stroke Risks in Primary Aldosteronism with Different Treatments: A Systematic Review and Meta-Analysis.
Frontiers in endocrinology, 2022 Aug 18
Cortisol values during the standard-dose cosyntropin stimulation test: Personal experience with Elecsys cortisol II assay.
The Journal of clinical endocrinology and metabolism, 2024 Dec 09
Performance of dehydroepiandrosterone sulfate and baseline cortisol in assessing adrenal insufficiency.

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