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Topics:
Endocrinology • Adrenal Disorders
What 60 minute cortisol threshold value do you use for diagnosis of adrenal insufficiency after ACTH stimulation?
Answer from: at Community Practice
It depends on the assay. Different assays measure different things. Mass spectrometry is the most accurate available assay at present, and it measures ONLY cortisol. Immunoassays also detect other related compounds, and vary from assay to assay as to which ones. Discussed in PMID 2...
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Answer from: at Community Practice
Based on our experience, we use a cortisol level >18 ug/dL at 60 minutes during the standard dose CST as the pass criteria. Husni et al., PMID 36060940
Answer from: at Academic Institution
When Cortrosyn is given IV, 18 or greater. However, a published study showed that 16 was sufficient if injected IM.
Answer from: at Community Practice
Cutoff 18 is universally accepted as a normal response, but anything closer is also fine.
Answer from: at Community Practice
Depends on the assay. Older assays, the answer was 18 for someone undergoing a standard 250mcg IV cosyntropin stim test. These days, the assays have less cross-creativity thus the cutoff is lower - 14-15 is about right.