Is there an indication for adrenalectomy in patients with subclinical Cushing syndrome and adrenal nodule?  

The short answer is "Yes". The indications for surgery depend on a number of factors, including the number of comorbidities and their severity and the degree of the HPA axis abnormality (1 mg DST and baseline ACTH/DHEAS level). We tend to be more aggressive with surgery in younger patients, although...