General Internal Medicine

Colorectal Cancer

Questions discussed in this category

Which patients, if any, treated according to PROSPECT for an early stage rectal cancer, would you offer surveillance if they achieved cCR after neoadjuvant chemotherapy?

Some patients have declined surgery knowing they achieved cCR. Would you observe or recommend chemoRT?

1 Answer available

How would you approach a stage II colon cancer with negative ctDNA but markedly elevated CEA level post-colectomy?

5 Answers available

What is your approach following R1 resection in a patient who has received total neoadjuvant therapy for rectal cancer?

1 Answer available

Which patients with rectal cancer who have not received neoadjuvant treatment do you offer adjuvant radiation to?

Is there a subset of patients you would avoid neoadjuvant CRT and operate first?

3 Answers available

When do you perform HER2 testing in patients with colorectal cancer?

1 Answer available

For elderly patients with locally advanced rectal cancer who are not candidates for surgery or chemotherapy, what would be an appropriate palliative regimen?

1 Answer available

Has pelvic MRI replaced EUS as the standard of care for rectal cancer staging?

Are there any indications to choose one over the other?

1 Answer available

Papers discussed in this category

J Can Assoc Radiol, 1975-09-01

The 1975 Gordon Richards Memorial Lecture. Is the Miles operation really necessary for the treatment of rectal cancer?

Int. J. Radiat. Oncol. Biol. Phys., 1995-01-15

Adenocarcinoma of the rectum treated by radical external radiation therapy.

Int. J. Cancer, 2017 Jun 08

What has preoperative radio(chemo)therapy brought to localized rectal cancer patients in terms of perioperative and long-term outcomes over the past decades? A systematic review and meta-analysis based on 41,121 patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-01-20

cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted.

J. Clin. Oncol., 2012-06-01

Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.

Lancet (London, England), 2007-12-15

Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study.

Annals of surgery, 1999-07

Long-term follow-up of patients with rectal cancer managed by local excision with and without adjuvant irradiation.

Journal of the National Cancer Institute, 2000-03-01

Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02.

Diseases of the colon and rectum, 2009-04

Long-term survival after transanal excision of T1 rectal cancer.

Radiother Oncol, 2012 Nov 28

Outcomes of unselected patients with pathologic T3N0 rectal cancer.

J Gastrointest Oncol,

Patterns of care and outcomes for adjuvant treatment of pT3N0 rectal cancer using the National Cancer Database.

Radiat Oncol J, 2019 Jun 30

Risk factors for locoregional recurrence in patients with pathologic T3N0 rectal cancer with negative resection margin treated by surgery alone.

Radiat Oncol, 2019 Jan 16

Tumor location as an indication for adjuvant radiotherapy in pT3N0 rectal cancer after surgery.

Radiat Oncol, 2014 Jul 22

In the era of total mesorectal excision: adjuvant radiotherapy may be unnecessary for pT3N0 rectal cancer.

Radiat Oncol, 2016 Sep 05

Adjuvant chemoradiotherapy instead of revision radical resection after local excision for high-risk early rectal cancer.

International journal of radiation oncology, biology, physics, 2011-01-01

Combined modality therapy including intraoperative electron irradiation for locally recurrent colorectal cancer.

Lancet (London, England), 2009-03-07

Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial.

International journal of radiation oncology, biology, physics, 1989-02

Long-term survival and patterns of failure after postoperative radiation therapy for subtotally resected rectal adenocarcinoma.

Int J Radiat Oncol Biol Phys,

Radiotherapy does not compensate for positive resection margins in rectal cancer patients: report of a multicenter randomized trial.

N Engl J Med, 2022 Jun 04

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer.

Nature medicine, 2008-09

Circulating mutant DNA to assess tumor dynamics.

Annals of oncology : official journal of the European Society for Medical Oncology, 2017-06-01

Plasma ctDNA RAS mutation analysis for the diagnosis and treatment monitoring of metastatic colorectal cancer patients.

The Cochrane database of systematic reviews, 2015 Dec 10

Blood CEA levels for detecting recurrent colorectal cancer.

Japanese journal of clinical oncology, 2002 Feb

CEA doubling time and CEA half-life in the prediction of recurrences after colorectal cancer surgery.

British journal of cancer, 2019 Apr 24

A multicentre, prospective study of plasma circulating tumour DNA test for detecting RAS mutation in patients with metastatic colorectal cancer.

N Engl J Med, 2023 Jun 04

Preoperative Treatment of Locally Advanced Rectal Cancer.

General Internal Medicine

Colorectal Cancer

Questions discussed in this category

Papers discussed in this category

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