General Internal Medicine

Sickle Cell

Questions discussed in this category

How long would you continue chronic transfusion therapy for adult sickle cell patients who have had a stroke?

Is treatment indefinite or do you consider discontinuing chronic transfusions at some threshold?

2 Answers available

How would you approach secondary stroke prevention in an adult with Hemoglobin SC disease?

Would you consider chronic RBC exchange versus HU?

1 Answer available

Is there any indication for hydroxyurea in patients with sickle cell trait?

2 Answers available

How do you manage hyperalgesia in patients with sickle cell disease?

1 Answer available

What are your recommendations for adult sickle cell patients who end up being admitted several times a year for pain crises despite hydroxyurea, crizanlizumab, voxelotor, etc?

What can you recommend that might help keep them out of the hospital? Do you consider a program of exchange transfusions in this situation?

2 Answers available

Is an elevated CRP an expected finding in an otherwise healthy patient with hemoglobin S - alpha thalassemia?

CRP 39 mg/L (normal < 10) and normal ESR

1 Answer available

How do you manage patients who develop minor antigen antibodies and require multiple blood transfusions?

e.g. K, Fya, s, etc

1 Answer available

How do you diagnose sickle hepatopathy?

1 Answer available

Is there an equivalent test for serum viscosity in sickle cell disease?

1 Answer available

Do hemoglobin S levels always correlate with SCD phenotype?

What is the lowest level you have seen with uncomplicated or complicated crises?

4 Answers available

Papers discussed in this category

N Engl J Med,

Sickle Cell Disease.

Blood Adv, 2020 Jan 28

American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.

Blood, 2019 Apr 25

The New England journal of medicine, 1994-03-17

High-dose intravenous methylprednisolone therapy for pain in children and adolescents with sickle cell disease.

Haematologica, 2013-09

A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes.

Blood, 1998-01-01

Cerebrovascular accidents in sickle cell disease: rates and risk factors.

Blood advances, 2020 Apr 28

American Society of Hematology 2020 guidelines for sickle cell disease: prevention, diagnosis, and treatment of cerebrovascular disease in children and adults.

Pediatric blood & cancer, 2011-12-01

Stroke With Transfusions Changing to Hydroxyurea (SWiTCH): a phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload.

The New England journal of medicine, 2021 Dec 12

Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease.

General Internal Medicine

Sickle Cell

Questions discussed in this category

Papers discussed in this category

Related Topics in General Internal Medicine