How do you manage patients who develop minor antigen antibodies and require multiple blood transfusions?  

Patients who develop antibodies to minor RBC antigens have shown themselves to be antibody responders and should receive limited matched red cells for Abs to C/c, E/e, and K antigens and extended matched red cells if the Abs are to Jka/Jkb, Fya/Fyb, S/s antigens. At-risk patient groups (sickle cell ...