General Internal Medicine

Sjogren’s syndrome

Questions discussed in this category

In a patient with sicca symptoms and SS-B antibodies only, can a minor salivary gland lip biopsy with lymphoid aggregates, but also scattered areas of acute neutrophilic inflammation be consistent with Sjogren's Disease?

Lymphoid aggregates consistent with Sjogren's Disease, but current criteria suggest that if the minor salivary gland lip biopsy has neutrophilic foci,...

2 Answers available

Do you always perform salivary gland biopsy to confirm the diagnosis In patients with suspected seronegative Sjogren's syndrome?

1 Answer available

In patients with sicca symptoms and positive SSA/SSB how often do you perform other diagnostic testing such as salivary gland ultrasound, biopsy, Shirmers, ocular staining, stimulated salivary flow, etc?

Is the diagnosis of Sjogren's mostly clinical in a patient with a consistent history and physical with positive serologies?

2 Answers available

How do you approach work up for underlying rheumatologic disease in patients referred for chronic urticaria?

2 Answers available

How do you approach hypocomplementemia in Sjogren’s without features of lymphoma?

3 Answers available

How do you approach management of a patient with Sjogren's disease and lung mass biopsy revealing amyloidosis?

1 Answer available

In patients with secondary Sjogren's how do you approach screening for lymphoproliferative malignancy?

What screening tests do you perform and at what intervals?

1 Answer available

How do you approach management of a patient with lower extremity ulcers from livedoid vasculopathy with a history Sjogren’s and Factor V Leiden?

4 cutaneous biopsies with no evidence of vasculitis. Sjogren’s diagnosis based prominent sicca symptoms and a significantly elevated SSA.

2 Answers available

In what circumstances do you pursue labial salivary gland biopsy in an asymptomatic patient with high titer ANA and positive SSA?

How do you risk stratify and monitor such patient for disease progression or organ involvement?

2 Answers available

When do you consider immunosuppression in patients with Sjogren's neuropathy?

3 Answers available

When performing salivary gland ultrasound for Sjogren's, what else do you include in the differential diagnosis?

1 Answer available

What is the diagnostic utility of ordering an "Early Sjogren's Syndrome Profile", which tests novel autoantibodies, to support a diagnosis of Sjogren's syndrome in patients who test negative for SSA/SSB?

1 Answer available

How do you treat small fiber neuropathy associated with rheumatic conditions like Sjogren’s syndrome?

1 Answer available

What baseline work-up or "staging" do you do in patients with a new diagnosis of Sjogren's (i.e., PFT, cryoglobulins, complement, RF, UA)?

1 Answer available

Papers discussed in this category

RMD open, 2015

EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide.

Arthritis Care Res (Hoboken),

Biopsy-Proven Small-Fiber Neuropathy in Primary Sjögren's Syndrome: Neuropathic Pain Characteristics, Autoantibody Findings, and Histopathologic Features.

Arthritis Rheumatol, 2016 Oct 26

2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts.

Clin Immunol, 2012 Oct 12

Novel autoantibodies in Sjogren's syndrome.

Chest, 2021 Feb

Consensus Guidelines for Evaluation and Management of Pulmonary Disease in Sjögren's.

Ann Acad Med Singap, 2012 Sep

A ten-year retrospective study on livedo vasculopathy in Asian patients.

The Journal of allergy and clinical immunology, 2012 Feb 14

Chronic urticaria and autoimmunity: associations found in a large population study.

Arthritis Rheumatol, 2021 Jul

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2021 Nov 12

Tissue biopsy for the diagnosis of amyloidosis: experience from some centres.

Radiographics : a review publication of the Radiological Society of North America, Inc, 2013 Nov-Dec

CT findings of thoracic manifestations of primary Sjögren syndrome: radiologic-pathologic correlation.

Journal of autoimmunity, 2012 Feb 06

Peripheral neuropathies in Sjögren's syndrome: a critical update on clinical features and pathogenetic mechanisms.

Rheumatology (Oxford, England), 2013 Oct 25

Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry).

Arthritis care & research, 2017 Oct 09

Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.

The Journal of rheumatology, 2021 May 01

Correlation Between Subjective and Objective Severity of Oral and Ocular Dryness in Primary Sjögren Syndrome.

Annals of the rheumatic diseases, 2002-06