In a patient with sicca symptoms and SS-B antibodies only, can a minor salivary gland lip biopsy with lymphoid aggregates, but also scattered areas of acute neutrophilic inflammation be consistent with Sjogren's Disease?

Lymphoid aggregates consistent with Sjogren's Disease, but current criteria suggest that if the minor salivary gland lip biopsy has neutrophilic foci, it cannot be evaluated for Sjogren's based on "current and accepted criteria".

Answer from: at Community Practice

Without additional information, it is hard to comment meaningfully. It depends on the number of glands harvested, the amount of glandular tissue available to the pathologist, and where the path was read. It is possible to submit the pathology for a second opinion to groups with expertise in Sjogren'...

Comments

at UTMB Health
Perhaps the presence of neutrophils reflects the p...

Answer from: at Community Practice

I agree with @Nancy L. Carteron and cannot speculate on the neutrophils.I'd also like to point out that a French study showed that only 1% of isolated anti-SSB patients had Sjogren's disease, SjD (Jardel et al., PMID 28931060); all others had other autoimmune diseases, neoplasia, infection, and soli...

Comments

at University of California, Berkeley and San Francisco
Thank you for your comments @Donald E. Thomas.

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In a patient with sicca symptoms and SS-B antibodies only, can a minor salivary gland lip biopsy with lymphoid aggregates, but also scattered areas of acute neutrophilic inflammation be consistent with Sjogren's Disease?

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