Do you always perform salivary gland biopsy to confirm the diagnosis In patients with suspected seronegative Sjogren's syndrome?   

No, but MSGB (minor salivary gland biopsy) can provide useful information, in addition to supporting the clinical diagnosis of Sjogren's disease (SjD), if the Focus Score is 3-4 or greater, the risk of lymphoma development is higher. For patients, if they are SSA/SSB negative, they often report hav...