Ophthalmology

General Internal Medicine

Questions discussed in this category

Is it safe to continue azathioprine in a patient with severe bilateral panuveitis (thought to be related to sarcoidosis) and benign ethnic neutropenia, given worsening neutropenia since starting the medication, or should an alternative immunosuppressive agent be considered?

Patient with a history of presumed benign ethnic neutropenia: PMN 1.5 prior to azathioprine and 1.2 after starting. The patient has an intolerance to ...

3 Answers available

How would you approach management of nodular scleritis in the setting of suspected GCA?

Can nodular scleritis be a presenting manifestation of GCA?

1 Answer available

In patients with sicca symptoms and positive SSA/SSB how often do you perform other diagnostic testing such as salivary gland ultrasound, biopsy, Shirmers, ocular staining, stimulated salivary flow, etc?

Is the diagnosis of Sjogren's mostly clinical in a patient with a consistent history and physical with positive serologies?

2 Answers available

Does a low serofast RPR titer (such as 1:1 or 1:2) in the setting of a remote history of appropriately treated latent syphilis in a patient with now uveitis of yet unknown etiology referred from ophthalmology for possible ocular syphilis make a diagnosis of ocular syphilis less likely?

What is your approach to guiding ophthalmologists regarding our clinical suspicion for ocular syphilis and does the quantification of the titer help i...

1 Answer available

Is there any benefit from oral vs topical steroids in herpes zoster opthalmicus?

Would the management change if there were complications with optic neuritis?

1 Answer available

How do you approach tapering immunosuppression in a patient with a history of Susac Syndrome who has stabilized on MMF and IVIG?

1 Answer available

Is it safe to use quinacrine in SLE patients with a history of hydroxychloroquine-associated retinopathy?

3 Answers available

Do you routinely obtain baseline vascular imaging (CTA, MRA, PET) in patients with suspected GCA, but negative temporal artery biopsy?

Per 2021 GCA Vasculitis Guidelines: low evidence, but conditional recommendation for CTA neck, chest, abd/pelvis. Is anybody following this or do you ...

2 Answers available

How would you approach management of incidentally identified unilateral retinal vasculitis with subsequent labs revealing +P-ANCA?

Patient is asymptomatic. Labs showed +P-ANCA 1:160. Negative MPO and PR3.

2 Answers available

How do you evaluate asymptomatic patients referred for benign intracranial hypertension?

If patients are asymptomatic, what work up do you typically proceed with?

3 Answers available

What is your approach to the workup for an underlying systemic condition in a patient presenting with retinal vasculitis?

1 Answer available

Can giant cell arteritis present with a partial cranial neuropathy?

3 Answers available

What is your approach to evaluation of underlying autoimmune disease in patients with bilateral scleromalacia?

1 Answer available

How do you diagnose and treat patients who develop uveitis while on bisphosphonate therapy for osteoporosis?

Are there specific features that suggest drug-induced uveitis versus de novo uveitis?

1 Answer available

What is your steroid-sparing agent of choice to treat GCA given the current tocilizumab shortage?

Thoughts on sarilumab vs methotrexate, or just treat with steroids alone

1 Answer available

How would you manage an active rheumatoid arthritis patient on suppressive antibiotic therapy for ocular HSV who has abnormal liver function tests?

1 Answer available

What are the benefits of sending HLA B27 genotype over HLA B27 antigen when evaluating for spondyloarthritis?

2 Answers available

At what point in GCA management do you typically introduce tocilizumab?

2 Answers available

Papers discussed in this category

N Engl J Med,

Trial of Tocilizumab in Giant-Cell Arteritis.

Lancet, 2016 Mar 04

Tocilizumab for induction and maintenance of remission in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial.

Curr Rheumatol Rep,

Polymorphism of HLA-B27: 105 subtypes currently known.

Ann Rheum Dis, 2011 Jul 28

HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis.

Curr Opin Rheumatol,

Retinal vasculitis.

Arthritis Rheum,

Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis.

JAMA Neurol,

The Dilemma of Diagnosing Idiopathic Intracranial Hypertension Without Papilledema in Patients With Chronic Migraine.

JAMA Neurol,

Prevalence of Incidentally Detected Signs of Intracranial Hypertension on Magnetic Resonance Imaging and Their Association With Papilledema.

Rheumatology (Oxford, England), 2015-03

Large-vessel giant cell arteritis: a cohort study.

Journal of the American Academy of Dermatology, 2017 Oct 06

Antimalarial drug toxicities in patients with cutaneous lupus and dermatomyositis: A retrospective cohort study.

Annals of the rheumatic diseases, 2023 Oct 12

EULAR recommendations for the management of systemic lupus erythematosus: 2023 update.

Journal of ophthalmic inflammation and infection, 2015-12

Clinical and laboratory characteristics of ocular syphilis: a new face in the era of HIV co-infection.

JAMA ophthalmology, 2024 Jan 01

Rising Incidence of Syphilitic Uveitis-Related Hospitalizations in the US.

Investigative ophthalmology & visual science, 2016 Feb

Clinical Manifestations and Outcome of Syphilitic Uveitis.

Arthritis Rheumatol, 2016 Oct 26

2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts.

Arthritis care & research, 2017 Oct 09

Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.

The Journal of rheumatology, 2021 May 01

Correlation Between Subjective and Objective Severity of Oral and Ocular Dryness in Primary Sjögren Syndrome.

Cureus, 2020 Jul 07

Biologic Therapies in Sarcoidosis and Uveitis: A Review.

Seminars in arthritis and rheumatism, 2015 May 21

Anti-TNF-α therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2011 Nov 27

Adalimumab successful in sarcoidosis patients with refractory chronic non-infectious uveitis.

Ophthalmology

General Internal Medicine

Questions discussed in this category

Papers discussed in this category

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