Primary Care

Major Depressive Disorder

Questions discussed in this category

What approaches have you found most helpful for concurrent severe major depressive disorder and alcohol use disorder?

3 Answers available

What strategies have you found helpful to manage SSRI associated night sweats?

4 Answers available

When do you choose to switch to antidepressants vs augmentation in treatment-resistant depression?

4 Answers available

How do you approach treatment-resistant depression and anxiety related to menopause refractory to SSRI/SNRIs and hormone replacement therapy?

1 Answer available

Would you consider over-the-counter dextromethorphan (low dose, slow titration) as augmentation in MDD?

Considering a growing interest in the use of dextromethorphan for depression (Majeed et al., PMID 33682569).

2 Answers available

How do you treat decreased libido from SSRIs?

Any alternatives to drug holiday, bupropion, sildenafil, and yohimbine?

12 Answers available

What do you do when a patient experiences multiple rounds of antidepressant-related tachyphylaxis?

4 Answers available

Papers discussed in this category

Clinical toxicology (Philadelphia, Pa.), 2008-09

Dextromethorphan-induced serotonin syndrome.

BMJ case reports, 2017-08-07

Serotonin syndrome caused by drug to drug interaction between escitalopram and dextromethorphan.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016-12-14

Aging Affects Dopaminergic Neural Mechanisms of Cognitive Flexibility.

Life (Basel, Switzerland), 2023 Apr 19

Pramipexole Augmentation for Treatment-Resistant Unipolar and Bipolar Depression in the Real World: A Systematic Review and Meta-Analysis.

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