Thrombosis   

Additional risk factors could be family history of VTE or thrombophilia, such as antithrombin deficiency.

Thrombophilia testing, including JAK2 is negative. When would you stop anticoagulation?

Thrombosis of the greater saphenous vein extending from SFJ to mid-calf, unchanged on follow-up Doppler imaging after 3 months of full dose rivaroxaba...

Cardiolipin was mildly positive and persistent after 12 weeks (29->28 MPL). No other significant provoking factors. The patient started on LMWH. W...

The patient takes frequent flights for their job, with no prior history of VTE, and has already been taking measures for prevention including frequent...

Would you anticoagulate for a fixed or indefinite duration? Would you recommend changing her contraception method?

Would you label this as intermediate or high risk and treat with prophylactic or full dose AC? What duration would you treat for?

No prior hx of DVT/SVT. Negative LE doppler. Would you consider anticoagulating and at what dose, or favor close observation?

BMI>40

Assume patient requires anticoagulation in the setting of acute thrombosis, with no need for IVC filter, but is approaching the end of her third trime...

Are the INRs reliable? In what scenarios would you not recommend POC INR use for warfarin monitoring? Are these typically covered by insurance? Are t...

Would you still plan for lifelong anticoagulation in this scenario? 

E.g. young male, morbid obesity, with BMI >50 

While follow up ultrasound is not usually recommended in provoked DVT, it often is done either for other reasons or by other physicians. Would this in...

Is patch or gel HRT with ASA prophylaxis a reasonable option after counseling? Or do you add a prophylactic DOAC? 

Is lifelong LMWH the anticoagulant of choice? Would DOACs be an option? 

Would you consider low dose indefinite anticoagulation in any scenario? Any difference in approach between hematological malignancy and solid tum...

No prior thrombosis; no family history of thrombosis. As per endocrine, the only useful therapy for the osteoporosis is estrogen. 

E.g. pulmonary embolism, portal vein thrombosis, cerebral venous sinus thrombosis

Would the answer differ if the index event was arterial vs venous? 

Previous provoking factors resolved (CVC, malignancy, etc)

If work-up is sent and the patient is found to have a persistently positive antiphospholipid antibody, particularly lupus anticoagulant, would you con...

Currently on nonwarfarin therapeutic anticoagulation

The patient has no personal history of VTE, but has positive family history of VTE.  Any prophylactic anticoagulation options? How would manage...

Is it time limited since it may have been triggered by the pregnancy or is it indefinite since it is APLS associated?

I.e., what constitutes well-controlled cancer, IBD, nephrotic syndrome, etc. What other diseases do you put in this category (obesity, autoimmune dise...

i.e. long car rides or plane rides

FVL heterozygotes are often treated similarly to the general population. Aside from avoiding other VTE risk factors, are there situations where prophy...

Would you offer indefinite anticoagulation if the event is unprovoked and the patient has low bleeding risk? 

If so, what agent(s) do you prefer?

What is your duration of anticoagulation?

Provoked or unprovoked VTE: Do you use D-Dimer (or even repeat imaging to reassess residual clot) in any capacity to guide anticoagulation duration? E...

Is there data that it actually helps?

While there are many factors involving:- type (DVT vs PE, unprovoked vs provoked) and severity of venous thromboembolism (VTE) size- duration of antic...

Do you follow the 2019 EULAR Guidelines that SLE patients with asymptomatic, positive aPL should be on low-dose ASA?

While thrombophilia testing is not routinely recommended prior to starting OCPs, how about after the development of a VTE?

Ref: EINSTEIN-CHOICE and AMPLIFY-EXT Would you approach this differently in patients with inherited thrombophilias?