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Questions discussed in this category

How do you counsel newly diagnosed patients with ALS on dietary recommendations?
Patients often see a dietician at ALS centers, but what do you discuss with patients before they have a formal consult with a dietician?
4 Answers available
How do you counsel patients with ALS on the benefits of enteral nutrition?
E.g., PEG tube placement.
3 Answers available
What nutritional supplements do you recommend for patients with ALS?
2 Answers available
How do you reconcile the benefits of high glycemic load to slow ALS disease progression with previous data on the increased risk for ALS associated with diabetes mellitus?
Particularly the increased risk for ALS in patients with DM in East Asian populations: Vasta et al., Neurological Sciences 2021.
2 Answers available
How clinically meaningful are the differences in the primary outcome between treatment and placebo groups in the CENTAUR trial?
Will these results change your practice?
5 Answers available
Do you use sitting vs supine spirometry to consider tracheostomy in a patient with Amyotrophic Lateral Sclerosis?
1 Answer available
Would the concerns about respiratory side effects from sodium phenylbutyrate and taurusodiol change your management of patients with predominantly bulbar ALS?
3 Answers available
How do you counsel patients on the side effects of sodium phenylbutyrate and taurursodiol?
3 Answers available
Do you typically assess plasma levels of the phosphorylated axonal neurofilament H subunit (pNF-H) in patients with ALS?
3 Answers available
Based on its mechanism of action, do you think sodium phenylbutyrate and taurursodiol could have benefit in other neurodegenerative disorders?
3 Answers available


Papers discussed in this category

Int J Mol Sci, 2022 May 24
The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress.
N Engl J Med, 2020 Sep 3
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010
Clinical significance in the change of decline in ALSFRS-R.
Brain and behavior, 2023 Apr 19
Type 2 diabetes, obesity, and risk of amyotrophic lateral sclerosis: A population-based cohort study.
Scientific reports, 2022 Feb 15
Association between type 2 diabetes and amyotrophic lateral sclerosis.
Clinical neurology and neurosurgery, 2020 Sep 28
Diabetes mellitus is associated with a lower risk of amyotrophic lateral sclerosis: A systematic review and meta-analysis.
JAMA neurology, 2015 Aug
Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Study.
Journal of epidemiology, 2015 May 02
Risk of Amyotrophic Lateral Sclerosis in Patients With Diabetes: A Nationwide Population-Based Cohort Study.
Muscle & nerve, 2015-09
Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010-12
A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS.
Journal of neurology, neurosurgery, and psychiatry, 2020 Jun 23
Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study.
Journal of neurology, 2023 Jun 28
The safety and effectiveness of high-calorie therapy for treating amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Annals of neurology, 2020 Jan 06
Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis.
Lancet (London, England), 2014-06-14
Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial.

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