Questions discussed in this category
The patient received adjuvant chemotherapy and had an unrevealing staging PET/CT.
When, if ever, do you utilize adjuvant RT or chemotherapy?
Would your systemic therapy choice be more similar to treatment of ovarian carcinoma or soft tissue sarcoma?
Does ER/PR status help guide your decision?
No sarcomatous overgrowth seen.
Would you consider adjuvant chemotherapy, radiation therapy, hormone therapy, or surveillance?
Final pathology showed grade 3 spindle cell sarcoma of thee vagina involving the anterior lateral cervix 5.6cm x 4.5 x 3.4cm, <0.1cm left lateral m...
Would you consider "neoadjuvant" hormonal therapy to shrink tumors and potentially make more amenable to complete cytoreduction at a later date?
Woul...
MRI with intravaginal gel shows no gross residual disease.
If so, would you treat the whole pelvis, cuff brachytherapy, or both?
In a patient, with multiple small volume lesions (5-25mm), would you offer pelvic RT?
Given the recent press release regarding the update on the phase 3 soft tissue sarcoma study of LARTRUVO (olaratumab) showing no benefit to the combin...
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Papers discussed in this category
Int J Clin Exp Med, 2015 Sep 15
Pathol. Int.,
Oncotarget,
Ann Surg Oncol, 2014 Aug
Cancer,
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2018-05-23
Acta Oncol, 2017 Apr 21
Lancet Oncol., 2017 Sep 04
Lancet Oncol., 2012 Sep 04
Gynecologic oncology, 2003-07
Obstetrics and gynecology, 2013-09
Lancet Oncol.,
Gynecol. Oncol., 2005 Dec 20
Int J Gynecol Cancer,
Gynecologic oncology, 2001-10
Int. J. Gynecol. Pathol.,
Eur. J. Cancer, 2008 Apr 02
J Clin Oncol,
Pediatric blood & cancer, 2018-02