Hematology

Nephrology

Questions discussed in this category

How do you counsel patients who experience diarrhea from mycophenolate mofetil (Cellcept)?

Do you generally recommend anti-diarrheals, dietary modifications, or consider this an unacceptable side effect and move to other therapies?

2 Answers available

How would you approach management of a patient with ESRD on the transplant list who is found to have high titer APS labs (ACL, B2GP1, LAC)?

1 Answer available

How would you approach post-operative VTE prophylaxis for renal transplant in patients with a prior history of provoked VTE?

Are there specific guidelines for managing this patient population?

1 Answer available

How do you monitor multiple myeloma in patients receiving dialysis?

Since free light chains are removed by dialysis and SPEP can also be impacted, is there a reliable way to monitor patients with ESRD and MM?

1 Answer available

How would you approach pursuing a kidney biopsy in a patient with suspected lupus nephritis who is on warfarin for antiphospholipid antibody syndrome?

2 Answers available

Will you use vadadustat in place of an ESA in treating anemia of chronic kidney disease?

2 Answers available

Do you avoid ESAs in patients with anemia and chronic kidney disease who also have Factor V Leiden?

1 Answer available

For patients with suspected complement-mediated TMA, are there specific clinical or laboratory parameters that can help guide the decision for starting empirical treatment (e.g., eculizumab) while awaiting the results of complement testing?

1 Answer available

What are your management strategies for patients with chronic kidney disease attributed to deferasirox use who require frequent blood products for a hematologic disorder?

1 Answer available

Do you avoid ESA use in patients with anemia and chronic kidney disease who also have APLS and risk for thrombosis?

2 Answers available

How do you dose apixaban in patients with CrCl <30 mL/minute?

1 Answer available

What are the factors that you would consider for the use of ESA in patients with anemia of CKD with a history of stroke or TIA?

1 Answer available

Do you consider starting hydroxyurea in a patient with hemoglobin S-beta thalassemia with chronic kidney disease secondary to FSGS?

No transfusion dependence but has hemoglobin in the 8-9 g/dl range.

1 Answer available

How is monoclonal gammopathy of renal significance (MGRS) different from myeloma kidney?

If there are light chain deposits on the kidney, is that conclusive of MGRS?

1 Answer available

Would you recommend complement testing in a kidney transplant recipient with chronic antibody-mediated rejection and biopsy-proven thrombotic microangiopathy to determine the need for eculizumab?

1 Answer available

Would you recommend oral or intravenous iron in a chronic kidney disease stage 4 patient who is not on an ESA and has a hemoglobin of 12.7 g/dl and an iron saturation of less than 20%?

3 Answers available

How do you manage recurrent hemodialysis filter clotting in an in-center ESKD patient with heparin-induced thrombocytopenia?

1 Answer available

Would you recommend use of ESA for anemia of kidney disease in the setting of metastatic solid tumor malignancy?

1 Answer available

Do you recommend starting aspirin for a patient with ESKD secondary to lupus nephritis with detected antiphospholipid antibodies on pretransplant workup but no history of a thrombotic event?

3 Answers available

Have you encountered acute kidney injury after starting eltrombopag for aplastic anemia as part of triple immunosuppressive regimen with ATG and cyclosporine?

1 Answer available

How do you manage anticoagulation bridging for outpatient ESKD patients given concerns for bleeding risk with enoxaparin in this population?

Would you bridge with enoxaparin 0.7 mg/kg/day in an ESKD patient, as described in a previous retrospective study (Pon et al., PMID: 24718051)?

1 Answer available

Would you consider clearing a patient with essential thrombocytosis for a kidney donation?

1 Answer available

Do you hold IV iron in the setting of active infection?

1 Answer available

How would you manage an incidental catheter-related thrombosis in a functioning dialysis catheter?

- Dialysis catheter used for hemodialysis- RIJ thrombus in dialysis catheter was incidentally found- Patient asymptomatic with no prior history of VTE...

2 Answers available

What is your preferred first line regimen for myeloma with severe renal impairment, either on or off dialysis?

1 Answer available

Is there any role for iron chelation in a patient with iatrogenic transfusion-induced iron overload such as in patients with end-stage kidney or liver disease?

Does transplant eligibility make a difference for management?

1 Answer available

Would you consider giving ESA for anemia secondary to chronic kidney disease in a patient with follicular lymphoma in remission and on rituximab maintenance?

1 Answer available

Papers discussed in this category

PLoS One, 2021 Apr 08

Effectiveness and safety of rivaroxaban versus warfarin in Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation: A real-world nationwide cohort study.

Am J Kidney Dis, 2019 Aug 05

The Use of Erythropoiesis-Stimulating Agents in Patients With CKD and Cancer: A Clinical Approach.

Circulation, 2022 Nov 06

A Randomized Controlled Trial Comparing Apixaban With the Vitamin K Antagonist Phenprocoumon in Patients on Chronic Hemodialysis: The AXADIA-AFNET 8 Study.

Circulation, 2022 Nov 06

Apixaban for Patients With Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial.

J Rheumatol, 2017 May 15

Longterm Hydroxychloroquine Therapy and Low-dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus.

Circulation, 2011-12-20

What caused excess strokes in patients randomized to darbepoetin in the trial to reduce cardiovascular events with Aranesp therapy (TREAT)?: no smoking gun.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013-01

Dose of erythropoiesis-stimulating agents and adverse outcomes in CKD: a metaregression analysis.

American journal of nephrology, 2013

Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease.

Journal of the American Heart Association, 2021 Jun 26

Erythropoietin Use and the Risk of Stroke in Patients on Hemodialysis: A Retrospective Cohort Study in Taiwan.

Therapeutic drug monitoring, 2022 Jun 01

Drug-Drug Interactions Between Mycophenolic Acid and Proton Pump Inhibitors: A Systematic Review and Meta-Analysis.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019 Jan 17

Update on the Native Kidney Biopsy: Core Curriculum 2019.

Nephrology (Carlton, Vic.), 2019 Oct 23

KHA-CARI Guideline recommendations for renal biopsy.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2021 Dec 06

Antithrombotic Management in Adult Kidney Transplantation: A European Survey Study.

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