Do you add adjunctive gentamicin and/or rifampin for treatment of prosthetic valve Staphylococcus aureus endocarditis?   

No, we do not add adjunctive gentamicin for treatment of Staphylococcus aureus (SA) prosthetic valve endocarditis (PVE). The potential benefit of using an aminoglycoside in this setting is minimal, if any, and is outweighed by the risk of toxicity.With respect to using rifampin, it depends on whethe...

I've been watching the data on this topic for a few years with great interest. I'm convinced that gentamicin is not worth the risks.  For Rifampin, it is often difficult to manage with my elderly population and all of their drug interactions. Apixaban is quite common in my people...

I would keep gentamicin for short duration until bacteremia resolved especially in patients without any kidney issues. And agree with others to use rifampin if no interactions or side effects.