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Topics:
Radiation Oncology • Gynecologic Cancers
Do you consider younger patients with NF2 to have a relative contraindication to radical pelvic RT due to risk of secondary malignancy?
In patients <50y/o, would you a favor a surgical approach in cervical malignancies that have pre-operative borderline Sedlis criteria indications for adjuvant RT?
Answer from: Radiation Oncologist at Academic Institution
Yes, I would consider NF2 to be a relative contraindication in a young patient. In the situation presented (borderline indications for post-op RT), I would likely lean toward up-front radical hysterectomy. However, if clear indications for post-op RT are present following surgery, I would not hesita...
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Answer from: Radiation Oncologist at Community Practice
The data on NF1 and malignancy is mainly with the transformation of benign tumors to malignancy with RT or new brain gliomas in the RT field. I am not aware of any such risk with pelvic RT unless cutaneous neurofibroma is in the radiation field and would not change management if RT is indicated.