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Neurology • Neuro-immunology
Do you ever check antibodies against EBV as part of a workup for MS in a patient with white matter lesions of unclear etiology on MRI?
Based on the results of the recent longitudinal analysis linking EBV infection and MS (Bjornevik et al., PMID 35025605), can negative EBV antibodies (although rare) be used to "rule out" MS?
Answer from: at Academic Institution
Generally, we do not check for antibodies against either viral capsid antigen (VCA) or Epstein Barr nuclear antigen (EBNA) for our patients with MS or when MS.EBV is considered a common infection. A large portion of the adult population, 90-95%, is seropositive for EBNA antibodies (Lincoln et al., P...
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