Do you ever consider the use of weekly (as opposed to bi-weekly bortezomib) for newly diagnosed multiple myeloma patients who are transplant eligible?   

As standard practice, I do this very commonly with a view to avoid neuropathy. If we do this , we modify the regimen to 3 weeks on bortezomib (days 1;8;15) and Lenalidomide 25 mg daily days 1-21 in the RVD combination. We plan to do 16 weeks (4 x 4 week cycles) prior to transplant. This is a modific...