Do you ever dose escalate radiotherapy to the primary in low volume metastatic prostate cancer?

Background: STAMPEDE Arm H (SOC ± RT to prostate) allowed for two fractionation schedules, 55 Gy in 20 daily fractions (67 Gy EQD2[α/β = 1.5]) and 36 Gy in 6 weekly fractions (77 Gy EQD2[α/β = 1.5]), without correction for treatment duration), and approximately half of participants received each sch...

Dr. @Dr. First Last gives an excellent and thorough answer. The only other thing I would add for comparison is the CHHiP trial itself and looking at the 57 Gy in 19 Fx vs 60 Gy in 20 Fx arms for comparisons of efficacy and toxicity.

5-year bPFS was 91% in the 60 Gy and 86% in the 57 Gy arms with a HR...