Do you give trastuzumab to women with small, lymph node negative, HER2-positive breast cancer?

Size, hormone receptor status, age, cardiac risk factors and patient opinion matter.

HER2 itself is only a moderately strong poor prognostic factor; histologic grade, size, and nodal status carry greater prognostic information. Most T1, N0, HER+ breast cancers, particularly ER+, cancers, had an excel...