Do you offer a curative surgery (Whipple procedure) to patients with duodenal adenocarcinoma, with 2-5 liver metastases, and with near CR after 3-6 months of FOLFOX chemotherapy?  

While Dr. @Jin correctly states that this is a rare situation and therefore a "data-free" zone, the answer may depend on how one perceives duodenal cancer: is it akin to colon cancer or more aligned with gastric or upper GI cancer? While small bowel and colon cancers exhibit several biological diffe...

Small bowel malignant tumors are uncommon. Estimated approximately 12,000 new cases and 2,000 deaths per year in the United States (compared to more than 150,000 new cases of colorectal cancer per year) and adenocarcinomas represent about 25-40% of the primary small bowel malignancies. Due to the un...

I highly agree with this. Because CRC can be curable even in the oligometastatic setting, we become accustomed to offering it. For example, partial hepatectomy to these patients (in combination c/ partial colectomy) to move forward with curative intent. But even in CRC, these cases should be caref...