Would you treat elderly patients with early-stage gastric cancer with perioperative FOLFOX or FLO (FLOT without T)?   

I am actually not sure why the official FLOT regimen used a 24-hour 5FU infusion. In the progression from the Mayo 5-day bolus regimen and the Roswell Park weekly regimen, the use of infusional 5FU reduced the toxicity of combinations with oxaliplatin and irinotecan. See the NCCTG N9741 study (Goldb...

My practice in this setting, where docetaxel is omitted from gastric cancer adjuvant therapy due to concerns about toxicity in the elderly, would be to use the FOLFOX regimen (with a 46-hour 5-FU infusion). To my knowledge, there are no efficacy data to guide the decision between a FLO-type regimen ...