Would you treat elderly patients with early-stage gastric cancer with perioperative FOLFOX or FLO (FLOT without T)?
How would the duration of 5FU infusion impact response?
Answer from: Medical Oncologist at Academic Institution
I am actually not sure why the official FLOT regimen used a 24-hour 5FU infusion. In the progression from the Mayo 5-day bolus regimen and the Roswell Park weekly regimen, the use of infusional 5FU reduced the toxicity of combinations with oxaliplatin and irinotecan. See the NCCTG N9741 study (Goldb...
Comments
Medical Oncologist at Montefiore Einstein Cancer Center Any reason to believe 2600 mg/m2 over 24 hours ind...
Answer from: Medical Oncologist at Academic Institution
My practice in this setting, where docetaxel is omitted from gastric cancer adjuvant therapy due to concerns about toxicity in the elderly, would be to use the FOLFOX regimen (with a 46-hour 5-FU infusion). To my knowledge, there are no efficacy data to guide the decision between a FLO-type regimen ...
Comments
Medical Oncologist at Montefiore Einstein Cancer Center If you start FLOT on anyone and drop docetaxel alo...
Medical Oncologist at Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center I'm answering this question regarding what regimen...
Any reason to believe 2600 mg/m2 over 24 hours ind...