Would you offer surgery for an MSI-H pancreatic adenocarcinoma who had deep response to pembrolizumab?

Patient presented with distant nodal disease and solitary liver metastasis and had normalization of CA19-9 from 22,827 at diagnosis, no evidence of distant disease on PET/CT and moderate FDG uptake in pancreatic head

Answer from: Medical Oncologist at Academic Institution

This is a hard question. The 19-9 gives me pause (even with normalization) and I think most likely I would push on with checkpoint inhibitor therapy for a total of two years given that it is very unlikely surgery will clear disease and ICI may get you to a durable complete response on its own. I don...

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Medical Oncologist at Locum Tenens
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Medical Oncologist
Would a biopsy help? If you did an EUS and bx and ...

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Would you offer surgery for an MSI-H pancreatic adenocarcinoma who had deep response to pembrolizumab?

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