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Topics:
Medical Oncology • Internal Medicine • Rheumatology • Hematology • Antiphospholipid Syndrome
Do you offer anticoagulation to patients with prior antiphospholipid antibodies detected in pregnancy without a history of pregnancy loss or thrombosis?
What is the risk of pregnancy loss in absence of anticoagulation? What would you suggest if the patient had anticoagulation in prior pregnancies and requests to continue for all future pregnancies?
Answer from: at Academic Institution
I do not know what the risk of pregnancy loss is in a woman without a prior history of VTE or pregnancy loss. I am sure the risk is affected by whether the woman has an underlying rheumatological disease (SLE) and whether she has single positive vs. triple positive LAC. I recommend a baby aspirin on...
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Answer from: at Academic Institution
Antovic et al., PMID 30364418 provided the following risk estimations: "High-risk aPL profile (LAC, triple positive, persistent moderate/high ACL in SLE) correlates with increased risk of maternal vascular thrombotic events during pregnancy (OR 12.1), pre-eclampsia (OR 2.3), APS-related pregnancy mo...
Answer from: at Academic Institution
May offer baby aspirin once daily.
Comments
at NIAMS
My experience with this in private practice and pa...
My experience with this in private practice and pa...