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Do you recommend maintenance immunotherapy after CR on chemotherapy for patients with metastatic TNBC?
In patients with prior perioperative immunotherapy with early relapse, would re-introduction of immunotherapy be reasonable with high TMB?
Answer from: Medical Oncologist at Academic Institution
The phase 2, KEYNOTE-158 study done in patients with metastatic solid tumors who progressed on at least 1 line of treatment, showed that 29% of 102 patients with TMB high status had an objective response compared to only 6% of 688 patients who had TMB low status, leading to FDA approval for tumor ag...
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Answer from: Medical Oncologist at Community Practice
Atezolizumab was granted accelerated approval by FDA in March 2019 based on data from the phase 3 IMpassion130 trial which demonstrated a statistically significant benefit to progression-free survival with the exploratory regimen vs placebo/chemotherapy (HR, 0.60; 95% CI, 0.48-0.77; P <.0001). Ho...