Do you recommend the use of GLP 1 R agonist therapy for obese women with PCOS who are actively trying to conceive?  

This is a very relevant question. GLP 1 RA therapy is recommended by the recently published International Consensus Guideline in Management of PCOS for assistance with weight loss in combination with lifestyle modification (Teede et al., PMID 37580314). The guideline states that this should be done ...

I will often use GLP1RA to help with weight loss in women with PCOS, with the added benefit of improving menstrual function and possible ease of conception down the road. However, I am clear that they should not be actively trying for pregnancy as we do not have sufficient safety data. When they hav...