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Male and Female Reproductive Disorders   

Questions discussed in this category

Do oral contraceptives lower bone mineral density in women with hypothalamic amenorrhea by lowering IGF-1?
1 Answer available
Is there any benefit of using aspirin to mitigate VTE risk in testosterone-induced polycythemia?
2 Answers available
Is there any evidence that spironolactone or finasteride therapy increase blood levels of testosterone?
2 Answers available
When do you recommend the use of oral testosterone replacement over injectable testosterone?
Ahmad et al., PMID 36106278
1 Answer available
What is the optimal anti androgen dose of spironolactone when treating female hirsutism?
1 Answer available
How long does it take the hypothalamic-pituitary-gonadal axis to recover from secondary amenorrhea in the setting early onset and chronic use of oral combined contraceptive pills?
1 Answer available
Do you recommend the use of GLP 1 R agonist therapy for obese women with PCOS who are actively trying to conceive?
Dao et al., PMID 38663923
2 Answers available
Is a history of provoked DVT a contraindication to starting testosterone replacement therapy in a middle aged man with symptomatic hypogonadism who is on anti-coagulation?
1 Answer available
In obese men presenting with gynecomastia, elevated estrogens, and hypogonadism, what clinical factors would push you to obtain testicular and/or adrenal imaging to rule out an estrogen-producing tumor?
Do you base the decision off of the acuity and course of symptoms? The degree of estradiol elevation? Other factors?
1 Answer available
Is active smoking a contraindication to starting menopausal hormone therapy (HRT) in a post-menopausal woman with severe vasomotor symptoms and no other cardiovascular risk factors?
1 Answer available
Do you recommend using anastrazole in men developing gynecomastia while on testosterone replacement treatment for hypogonadism depending on pre-treatment estradiol level?
1 Answer available
Should testosterone replacement be stopped in elderly men who suffered acute stroke even when testosterone levels have been stably in the low-to-mid normal range?
1 Answer available
Would you recommend prescribing testosterone replacement therapy to reduce osteoporosis fracture rates in men with hypogonadism?
1 Answer available


Papers discussed in this category

The New England journal of medicine, 2023 Jun 16
Cardiovascular Safety of Testosterone-Replacement Therapy.
The New England journal of medicine, 2013 Sep 12
Gonadal steroids and body composition, strength, and sexual function in men.
The Journal of clinical endocrinology and metabolism, 2023 Sep 18
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
European journal of endocrinology, 2018 Apr 27
Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
BMJ open, 2024 Apr 24
Use of GLP1 receptor agonists in early pregnancy and reproductive safety: a multicentre, observational, prospective cohort study based on the databases of six Teratology Information Services.
Clinical endocrinology, 1978 Nov
Endocrine effects of spironolactone in man.
The Journal of steroid biochemistry and molecular biology, 2013 Mar 06
Effect of finasteride on serum levels of androstenedione, testosterone and their 5α-reduced metabolites in men at risk for prostate cancer.
The Journal of clinical endocrinology and metabolism, 2007-05
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.
The Journal of clinical endocrinology and metabolism, 1975 Oct
Effect of spironolactone on sex hormones in man.
Clinical endocrinology, 1978 Dec
Increased serum oestrone and oestradiol following spironolactone administration in hypertensive men.
The Journal of clinical endocrinology and metabolism, 2018 May 01
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
The Journal of urology, 2022 Jan 20
Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy.
Haematologica, 2009 Oct 14
Hematocrit and risk of venous thromboembolism in a general population. The Tromso study.
American journal of hematology, 2023 Jul 20
Sodium-glucose co-transporter-2 inhibitor therapy and unmasking of JAK2-mutated myeloproliferative neoplasm: A Mayo Clinic series of nine consecutive cases.

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