Is there any evidence that spironolactone or finasteride therapy increase blood levels of testosterone?
Answer from: at Community Practice
Yes. It seems that both medications can do this at least in the short term. Spironolactone's effect may be more temporary.For spironolactone, an older article: Tidd et al., PMID 152681For finasteride: Stanczyk et al., PMID 23474436
Finasteride and dutasteride block 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone. As one might expect, serum testosterone increases, but only modestly (10-20%) in cis-men.
Amory et al., PMID 17299062
Spironolactone has minimal, if any effects, on serum testosterone...