Do you still consider the use of pegloticase in someone with substantial tophaceous burden despite optimal uric acid levels?

For example, patient with sUA <4 already on maximum dose allopurinol or Uloric, but significant tophi that have only marginally reduced in size.

Answer from: at Community Practice

If a patient has a significant burden of tophaceous deposits causing functional impairment despite serum uric acid control achieved through oral uric acid lowering therapy (ULT), I strongly recommend considering a course of enzymatic therapy with pegloticase. Terms such as “treatment failure g...

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at Duke University Medical Center
Thank you, this has been similar to my practice bu...

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Do you still consider the use of pegloticase in someone with substantial tophaceous burden despite optimal uric acid levels?

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