Does the presence of asparaginase antibodies on Granger Genetics testing indicate need to switch asparaginase formulations?
Answer from: at Academic Institution
I would rely on the serum asparaginase activity (SAA) assay rather than the antibody testing. SAA has proven to be a reliable predictor of asparagine depletion and is a widely acceptable method for therapeutic drug monitoring. On the other hand, asparaginase antibody testing has not been consistentl...